MICRO-ENVIRONMENTAL MECHANICAL STRESS CONTROLS TUMOR SPHEROID SIZE AND MORPHOLOGY BY SUPPRESSING PROLIFERATION AND INDUCING APOPTOSIS IN CANCER CELLS.

Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the Games dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved.We co-embedded single cancer cells with fluorescent micro-beads in agarose gels and, usin

Misalignment between career and education aspirations has been associated with poorer achievement during adolescence and unstable employment in adulthood.In this study, we evaluated whether a brief in-school intervention improved career decision self-efficacy and aspirational alignment.We sampled 211 teenagers living in disadvantaged areas of Signs

Molecular chaperone Hsp104, also known as heat shock protein in yeast Saccharomyces cerevisiae, plays an essential role in thermotorelance response enabling yeast cell survival at high temperature.Hsp104 mediates the misfolding and the aggregation of denatured proteins to refold to their native forms.In addition, it has also reported CELLOPHANES CH

Numerous studies have investigated the emotional effects of various acute, potentially alarming events in animals, but little is known about how an accumulation of emotional experiences affects fearfulness.Fearfulness is a temperament trait that characterizes the propensity of an individual to be frightened by a variety of alarming events.The aim o

In a previous work [Pasini L and Sabatini S 2016 TASK Quart.20 (1) 9], we Dog Treats described a technique that allows a specific system of urban traffic to be associated to a description file system, called Model.dat.This file contains a list of data objects that are defined in the library [Pasini L and Feliziani S 2013 TASK Quart.17 (3) 155] and